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(Reuters) – The report quickly serious and unexpected possible side effects of drugs his has warned because of non-conversion the US Food and Drug administration Pfizer Inc already at the market.

In a 12-sided reminder in Pfizer Chief Executive Jeffrey Kindler, drug Viagra, the cholesterol pill Lipitor and seizure medicine Lyrica cites the FDA numerous examples, in some of the top enterprises of known brands, including impotence.

The delays by the reporting side effects time so far back like in 2004 and have strongly grown during the last years, accordingly of the FDA that the writing was published by Pfizer on Wednesday.

Ronald Pace, manager of the FDA office in New York, said Pfizer in the writing from the 26th of May, it would not be documented properly or examines the reported problems with patients after the drugs for the use were admitted.

“To create medicament manufacturer FDA and to move adequate mechanisms to make sure that all serious and unexpected experiences grasp in a contemporary way and expect examined” wrote Pace.

Pace asked Kindler to a meeting between the enterprise and the agency about the injuries to arrange. Pfizer said, it received the letter 3rd of June.

A 6-weekly inspection of Pfizer’s headquarters led the FDA in New York in July and August of 2009, where the inspectors of the organisation found system-wide frail in the world-biggest pharmaceutical company.

The patient reports “to serious and unexpected side effects contain… this were first are submitted which they were ascertained during the FDA inspection,” Pace wrote. To repair the efforts towards the problem “were proved as ineffective”, he added.

In an explanation said Pfizer it would be with the FDA work together, around the agency “correspond and an optimum supervision to guarantee and reporting of postal marketing side effects.”

But one also said that such individual reports only one part of his general examination of the drugs sold by him and that they “believes” We offer complete and exact data to the use to determine and to allow the risk profile for all our drugs and, are for their sure and adequate use.”

In her writing, cites the FDA several examples of the reporting frail.

For example, around during cialis vs viagra and similar drugs are known serious visual disturbances, including blindness, Pfizer was able to do to cases in connection with his drug within the agency 15-days term report “from misclassifying and / or downgrading reports not seriously, without reasonable justification.”

And now secludedly painkiller Bextra of Pfizer, FDA grants the enterprise a freeing from 60 days to allow, possible objections, a time window the pharmaceutical company still missing.

Pfizer said the FDA first accused the problems on a new EDP system to the reports Clutch, say employees were not trained properly. In a reaction September, 2009 to the agency, Pfizer said the agency user’s handbooks would become to update, better her employees in the electronic registration system and other measures seize.

In spite of these steps, said the FDA in her writing that the measures of the enterprise “have been insufficient.”

Pfizer explained the FDA that the reporting were not included after May, 2009, but all data protect this claim improved, explained the FDA. In addition, the enterprise does not have to prove to the FDA that it all employees she said, it would be trained.

According to the FDA, the enterprise delays at the agency tell about announced discomfort have only grown. About 4 percent of the Pfizer 80,560 reports became at the end of March, 2006 till December, 2008 sent compared to 9 percent from December, 2008 to June, 2009, said the letter.

In addition, does not quote of the FDA Pfizer for immediately tells the FDA about thefts and considerable losses of her drugs.

FDA’s Pace applies for an immediate meeting and asked for the problems within 15 days, or an explanation intended if it last longer are settled. Besides, he demanded, Pfizer, a revised plan to present to repair the problems.

To repair with nonobservance of the problems could reserve juridical steps result and the FDA could delay measures with the approval of the enterprise pending to drugs, among the rest, sanctions, said Pace in the writing.